mechanism of action

 MC1101’s mechanism of action:

The fundamental difference between dry AMD and wet AMD is the integrity of the Bruch's Membrane. MacuCLEAR's mechanism of action prevents the rupture of this critical blood barrier as it:

  1. Restores choroidal blood flow
  2. Controls inflammation
  3. Restores retinal pigment epithelium (RPE) function through anti-oxidative effects

 

MacuCLEAR's approach to treating Dry AMD has found support in the works of several AMD researchers, most recently in an editorial by Dr. Ephraim Friedman:

  •“The etiology of AMD, I believe, is largely attributable to impairment of choroidal perfusion. Atherosclerosis in­creases scleral rigidity. Scleral rigidity, in turn, interferes with choroidal venous drainage of retinal lipoproteins; and, finally, the accumulation of these lipoproteins is responsible for the retinal damage seen in early AMD.”

•“The model suggests that treatment of early AMD can be best accomplished by prevention or treatment of systemic atherosclerosis ……by treating scleral rigidity directly.”
•“Other theories of AMD are compatible with progression and late AMD, including…. oxidative damage .... and inflammation.”
 
The Pathogenesis of Age Related Macular Degeneration-Ephraim Friedman, MD; Am J Ophthalmology, 2008, Editorial